Mesotherapy is a technique to rejuvenate and tighten skin, and get rid of excess fat. This technique that uses very fine needles to deliver a series of injections into the middle layer (mesoderm) of skin. What Mesotherapy is used for: Removing fat in areas like the stomach, thighs, buttocks, hips, legs, arms, and face and also improve the appearance of cellulite and tighten loose skin.